Demethylepipodophyllotoxin

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August undefined, 2024

Web4'-Demethylepipodophyllotoxin (4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly. For research use only. We do … Web新闻网站阅评部的竞聘演说各位领导,各位同事:大家好.今天能坐在这里参加竞聘,向大家汇报一下我个人对于工作的一些想法,我感到很骄傲.之所以感到骄傲,是因为我一直认为,工作这件事,对于我们每个人来说,既是为我们的公司为我们的服务对象服务,同时也,文库 …

Discover the leading compound of 4β-S - ScienceDirect

Web4'-Demethylepipodophyllotoxin is an antimitotic agent which binds to monomeric tubulin, preventing micro-tubule polymerization. It is a potent inhibitor of microtubule assembly. Bioorg Med Chem. 2014 Jun 1;22 (11):2998-3007. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O- (2-pyrazinecarboxylic ... WebA method for synthesizing a 4'-demethylepipodophyllotoxin of formula (II) from a podophyllotoxin of formula (I) by treating it with a pair of reagents, i.e. a strong acid and … corporate office kitchens

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WebDec 15, 2024 · Screening results revealed that 4'-demethylepipodophyllotoxin (DMEP) from renewable Dysosma versipellis (D. versipellis) species could distinctly decrease … WebFor use with the X500R QTOF system powered by SCIEX OS WebAccording to the structure of podophyllotoxin and its structure-function relationship, a novel tandem biotransformation process was developed for the directional modification of the … farbtemperatur win 10

4′-Demethylepipodophyllotoxin SDS, Safety Data Sheets - ECHEMI

WebUsing the anti-tumor drug VP16 (demethylepipodophyllotoxin-beta-D-glucoside) with purified topoisomerase II, we identify twelve sites. Five sites are clustered around position -306 in a region that possesses enhancer-like properties. A second cluster of three sites is positioned 15 bp upstream of the TATA promoter element. WebJun 5, 2024 · Indocyanine green (ICG) has been reported as a potential near-infrared (NIR) photosensitizer for photodynamic therapy (PDT) of cancer. However the application of ICG-mediated PDT is both intrinsically and physiologically limited. Here we report a combination of ICG-PDT with a chemotherapy drug etoposide (VP-16), aiming to enhance the … corporate office k-va-t food stores incWebToxic side-effects included nausea, vomiting, diarrhea, fever, alopecia, leukopenia, and thrombocytopenia. These results, the first reported with both NSC-122819 and NSC … corporate office kitchen design

"WebSep 1, 2024 · Biological modification of natural products is an important approach to improve the pharmacological properties. 4′-d-β-Demethylepipodophyllotoxin (4′-d-β-DMEP), a … " - Demethylepipodophyllotoxin

Demethylepipodophyllotoxin

Web4'-Demethylepipodophyllotoxin C21H20O8 CID 122797 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, … WebAccording to drug design flattening principle and using podophyllotoxin or 4'-demethylepipodophyllotoxin and aldehydes as starting material,a series of podophyllotoxin derivatives containing an imine structure with low toxicity were highly effective synthesized. Nine target compounds were successful …

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WebThe first purposes of this invention is to provide 4′-demethylepipodophyllotoxin derivatives showing good water-solubility and good anti-tumor activity; the second purpose of this …

WebMolecular Weight: 588.56. Compare. Product No. Description. SDS. Pricing. 341205. A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC₅₀ = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. WebOct 5, 2024 · Abstract. 4'-Demethylepipodophyllotoxin (DMEP) derivatives are broad-spectrum and potent antitumor leading compound. Because of their unacceptable …

WebJan 14, 2024 · 4'-Demethylepipodophyllotoxin (4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of … WebJun 1, 2014 · A rational design strategy of the novel podophyllum topoisomerase II (Topo II) inhibitors for the synthesis of the esterification and amidation substituted 4'-demethylepipodophyllotoxin (DMEP) derivates was developed in order to discover the potential antitumor prodrug.

WebNov 2, 2006 · A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared ones, for their cytotoxic activities against four tumor cell lines (HL60, P388, A549 and BEL7402). Three of these compounds exhibited superior in vitro anticancer activity against P388 …

WebApr 30, 1990 · The 4'-demethylepipodophyllotoxin glycosides of the present invention are prepared by condensing 4'-protected 4'-demethylepipodophyllotoxin with an appropriately protected sugar. 4'-Protected 4'-demethylepipodophyllotoxins are known in the art; for example, 4'-carbobenzyloxy-4'-demethylepipodophyllotoxin and its preparation are … farbtheorie goetheWebNov 2, 2006 · A series of new 4β-5-Fu-substituted 4'-demethylepipodophyllotoxin derivatives were synthesized and evaluated, together with some previously prepared … corporate office in turbheWebCas No.: 40505-27-9 Formula: C 21 H 20 O 8 Mol Weight: 400.383 Botanical Source: Podophyllum emodi, Podophyllum polygama and other Podophyllum spp. also root of Dysosma majorense Purity: 95%~99% Analysis Method: HPLC-DAD or/and HPLC-ELSD Identification Method: Mass, NMR Packing: Brown vial or HDPE plastic bottle farbtheorie ittenWebDec 15, 2024 · The screening platform for FtsZ inhibitors was established for controlling plant bacterial diseases. • The natural 4'-demethylepipodophyllotoxin (DMEP) exhibits good bioactivities against Xanthomonas oryzae pv. oryzae. The natural DMEP can serve as a novel lead compound for exploring highly bioactive FtsZ inhibitors. farbtheorie definitionWeb4'-demethylepipodophyllotoxin (DMEP) belongs to the class of podophyllotoxin. Podophyllotoxin is a natural product from the roots and rhizomes of Podophyllum species … farbtheorie itenWebJun 10, 2014 · According to the structure-activity relationship, drug combination principle and bioisosterism, a series of the novel esterification and amination 4'-demethylepipodophyllotoxin derivates were rationally designed in order to discover the potential antitumor prodrug. And then these compounds were test … corporate office interior designers in mumbaiWebUsing the anti-tumor drug VP16 (demethylepipodophyllotoxin-beta-D-glucoside) with purified topoisomerase II, we identify twelve sites. Five sites are clustered around position -306 in a region that possesses enhancer-like properties. A second cluster of three sites is positioned 15 bp upstream of the TATA promoter element. farbtheorien