He and klionsky fundc1

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Web10 de may. de 2024 · FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). This ... Web22 de ene. de 2012 · Chen and colleagues show that FUNDC1, an integral mitochondrial outer membrane protein, interacts with light chain 3 (LC3) and is essential for hypoxia …

FUNDC1蛋白调控线粒体形态和细胞凋亡的研究

Web12 de abr. de 2024 · Abstract. This study aimed to determine if there is an association between mitophagy and refractory temporal lobe epilepsy (rTLE) with hippocampal sclerosis. During epilepsy surgery, we collected tissue samples from the hippocampi and temporal lobe cortexes of rTLE patients with hippocampal sclerosis (as diagnosed by a pathologist). http://fund.keyanzhiku.com/Index/info/id/NDQ4NzQ5MTQ0YmllLXNoaS1sZS1xdS1iaWUtcmVuLWppYS1wYS1zaHUtanUtYmE%3D.html number 11 bus inverness

(PDF) Molecules and their functions in autophagy - ResearchGate

WebAn X-linked lysosomal storage disease marked by progressive symptoms including burning pain in the hands and feet, sweating, and purple skin lesions, with death resulting from … Web10 de may. de 2024 · FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria … Web23 de feb. de 2024 · PINK1 is a Ser/Thr kinase with a C-terminal kinase domain and N-terminal mitochondrial targeting sequence 55, and PRKN/PARK2 (also known as parkin) … number 11 bus shrewsbury

FUNDC1-dependent mitochondria-associated endoplasmic …

The machinery of macroautophagy - PubMed

Web5 de dic. de 2024 · FUNDC1 was initially reported to stimulate mitophagy in response to hypoxia. 9 This protein binds to LC3 proteins and operates as an autophagy receptor, and its activity is stimulated by phosphorylation catalyzed by ULK1 10 or by dephosphorylation by PGAM5. 10 In addition, FUNDC1 has been documented to accumulate at … WebTakeshi Noda 1 , Daniel J Klionsky. Affiliation 1 Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. PMID: 19185711 DOI: 10.1016/S0076-6879(08)03203-5 Abstract The measurement of ... number 11 basketball playerWeb19 de abr. de 2024 · FUNDC1是一种跨膜蛋白，位于线粒体外膜上，具有3个α螺旋，其中膜外的N端氨基序列中包含一段保守LIR，由此区域可以与LC3相互作用以介导低氧诱导的线粒体自噬[16]。正常情况下FUNDC1通过与内质网膜钙调蛋白的链接，在MAM处聚集；缺氧时FUNDC1/钙调蛋白的链接变弱，继而DRP1因与FUNDC1结合后被募集到MAM，线粒体 … number 11 bus stoke on trent

"Web1 de feb. de 2012 · FUNDC1 is a novel mitochondrial outer membrane protein, which starts mitochondrial autophagy by binding LIR domain with LC3, and belongs to the pathway of receptor-mediated mitochondrial... " - He and klionsky fundc1

He and klionsky fundc1

Ulk1/FUNDC1 Prevents Nerve Cells from Hypoxia-Induced

WebWe recently identified Fundc1 as a new mitophagy receptor and demonstrated that ULK1 expression is upregulated by either hypoxia or FCCP. When mitochondrial autophagy occurs, ULK1 translocates to mitochondria, while the level of serine phosphorylation of FUNDC1 increases. WebDaniel Klionsky, Ph.D. Research Professor, Life Sciences Institute Alexander G. Ruthven Professor of Life Sciences, Department of Molecular, Cell & Developmental Biology, U-M College of Literature, Science, and the Arts (734) 615-6556 [email protected] Research Staff Hana Popelka, Ph.D. Research Laboratory Specialist [email protected]

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WebImmunoprecipitation of FUNDC1 protein from A-673 cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900, and lane 3 is FUNDC1 (E2F4T) Rabbit mAb. Western blot analysis was performed using FUNDC1 (E2F4T) Rabbit mAb. Anti-rabbit IgG, HRP-linked Antibody #7074 was used as a secondary antibody. Web5 de abr. de 2010 · Before that, Klionsky, a California native, was a biology major at UCLA and a graduate student at Stanford, investigating the bacterial ATP synthase with Bob …

WebFUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells. Upon mitochondrial stress, … Web16 de dic. de 2024 · In addition, FUNDC1 can be enriched at contact sites between mitochondria and the endoplasmic reticulum (ER), determining the formation of …

WebAge-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with limited understanding of its pathogenesis and a lack of effective treatment. The progression of AMD is initially characterized by atrophic alterations in the retinal pigment epithelium, as w … Web4 de may. de 2016 · Figure 1. FUNDC1 is a novel MAM protein and accumulates in the MAM under hypoxic conditions. Immunoblots of subcellular fractions from HeLa cells exposed to normoxia. P: post-nuclear supernatant; C: cytosol; ER: endoplasmic reticulum; MT: mitochondria; MA: mitochondrial-associated membranes.

WebThe machinery of macroautophagy Authors Yuchen Feng 1 , Ding He 1 , Zhiyuan Yao 1 , Daniel J Klionsky 1 Affiliation 1 Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. PMID: 24366339 PMCID: PMC3879710 DOI: 10.1038/cr.2013.168 Abstract

Web5 de abr. de 2024 · As a key receptor of mitophagy, FUNDC1 also plays an important role in many kinds of human diseases, especially in cardiovascular diseases. In obese mice … number 11 beaulyWebFUNDC1 驻留在线粒体外膜蛋白上，调节线粒体动力学和缺氧诱导的线粒体吞噬 (2-4)。它包含一个氨基末端 LC3 相互作用区 (LIR)，负责与 LC3 相连并将线粒体募集到自噬体。 FUNDC1 的磷酸化状态可以通过影响其与 LC3 的结合来调节其活性 (4-6）。在正常条件下，FUNDC1 在 Tyr18 处被 Src 磷酸化，这在缺氧过程中被抑制，从而导致去磷酸化 (4)。 … number 11 bus swindonWeb10 de dic. de 2024 · FUNDC1 is a new OMM protein that promotes mitochondrial fragmentation and mitophagy during hypoxia ( Liu et al., 2012; Zhang et al., 2016a; … number 11 bus timetable bodminWeb21 de mar. de 2024 · anti-FUNDC1 antibody (FUN14 Domain Containing 1) N-Term. Biorbyt antibodies for FUNDC1. orb1193847. orb1240756. Boster Bio Antibodies for FUNDC1. A08688. Boster Bio Custom Antibody Services (starting from $600), Antibody Validation Service, WB Service, IHC Service, and Multiplex IHC Service. nintendo first party games 2023Web29 de feb. de 2012 · He C, Klionsky DJ. Regulation mechanisms and signaling . pathways of autophagy. Annu Rev Genet 2009;43:67-93. He C, Levine B. The Beclin 1 interactome. Curr Opin Cell Biol . 2010;22:140-9. nintendo first game release dateWebUnc-51 like autophagy activating kinase 1 (Ulk1) and FUN14 Domain-containing Protein 1 (FUNDC1) are both involved in the regulation of cell autophagy. This study aimed to … number 11 bus timetable kilmarnock to irvineWeb11 de abr. de 2024 · FUNDC1 is a mitochondrial receptor for hypoxia-induced mitophagy, which can be negatively regulated by Src kinase and casein kinase 2 . number 11 activity sheet