Web6 de ago. de 2015 · The ORR of 67% and the DOR of 17.5 months observed in our study are the highest reported for a single agent in R/R MCL. The median PFS of 13 months and OS of 22.5 months in this long-term follow-up analysis remain consistent with our prior report 8 and further confirm the efficacy profile of ibrutinib in this setting. Web22 de dez. de 2024 · Football agent David Mulugheta made the biggest jump on this year's list, catapulting 30 spots to No. 8 with more than $1.5 billion in negotiated deals and …
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WebHere, we compare the behaviour of four synergy models, namely Loewe additivity, Bliss independence, highest single agent and zero interaction potency, using the Merck oncology combination screen. We evaluate agreements and disagreements between the models and investigate putative artefacts of each model's assumptions. Webvt. 拣出，选拔。 single out the biggest apples 拣出最大的苹果。 vi. 1.【棒球】作一垒手。 2.(马)单步行进。 n. -ness 单一，单独；诚意。 "the single" 中文翻译: 单身贵族 "agent … Web13 de nov. de 2024 · Intriguingly, among specimens from 100 unique ALL patients, we also observed that IBR+VEN demonstrated significantly enhanced efficacy by AUC and IC50 compared to either single agent (p<0.001; median IC50=0.018 µM). In contrast, evaluation of this combination on primary mononuclear cells from two healthy donors showed little … cannabeer beer squad