Higuchi and connors

Author: boji

August undefined, 2024

WebT. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Ibuprofen-Maltodextrin Interaction: Study of Enantiomeric Recognition and Complex Characterization WebFeb 27, 2010 · According to Higuchi and Connors there can be five types of phase-solubility relationship (Fig. 1 ): A L -type where there is a linear relationship between substrate (drug) solubility and ligand (cyclodextrin) concentration and which is interpreted as formation of a complex with m :1 stoichiometry; A P -type, which represents positive deviation …

Phase solubility studies of terpineol with β-cyclodextrins and ...

WebThe present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ... http://www.sciepub.com/reference/10360 flagging someone with a firearm

Phase solubility techniques Semantic Scholar

WebT. Higuchi and K. A. Connors, “Phase-Solubility Tech-niques,” Advances in Analytical Chemistry and Instru-mentation, Vol. 53, No. 4, 1965, pp. 117-212. - References - Scientific … WebJan 15, 2024 · Natural CDs and their derivatives are used as enabling pharmaceutical excipients that enhance aqueous solubility of poorly soluble drugs, increase drug permeability through biological membranes and improve drug bioavailability. WebHiguchi and Gensch, "Acylation through a Sulfonium Ion Intermediate. Coupled Conversion of a Carboxylic Acid to an Acid Anhydride during Oxidation of a Thioether to a Sulfoxide,", … flagging tape tractor supply

Binary and Ternary Complexes of Arteether β-CD

Solubility enhancement and application of cyclodextrins in

WebIn vitro transdermal permeation behavior of isosorbide dinitrate in the absence and presence of 2-hydroxypropyl-β-cyclodextrin: solutions and suspensions. Interactions of a vasodilator, isosorbide dinitrate (ISDN), with the parent α-, β- and γ-cyclodextrins (α-, β- and γ-CDs) and 2-hydroxypropyl-α- and -β- and γ-CDs (HP-α- and -β ... WebSep 1, 2010 · The phase-solubility diagrams obtained according to the Higuchi and Connors method [6] allowed us to estimate the molar ratio and the apparent stability constants of … flagging the issue meaningWebHiguchi et. al, "Phase-Solubility Technique in Studying the Formation of Complex Salts of Triamterene,", 1964. Higuchi and Connors, "Phase-Solubility Techniques,", 1964. Higuchi … flagging test answers

"WebThe most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that … " - Higuchi and connors

Higuchi and connors

Phase solubility diagrams and their classification according to Higuchi …

WebThis was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for determination of the stability constant of a drug whose physicochemical and spectroscopic analyses are difficult, because they can be calculated by monitoring the solubility ... WebMay 1, 1999 · There are many methods for determination of stability constants of CyD complexes, using techniques such as solubility ( Higuchi and Connors, 1965 ), potentiometry ( Miyaji et al., 1976 ), high-pressure liquid chromatography ( Uekama et al., 1978 ), and kinetic ( Bender and Komiyama, 1978) and spectroscopic ( Cramer et al., 1967, Thakkar et …

Did you know?

WebSolubility profiles by Higuchi and Connors theory. So is the drug intrinsic solubility in cyclodextrin absence 76 . Source publication Alternative Technologies to Improve … WebMay 1, 1999 · There are many methods for determination of stability constants of CyD complexes, using techniques such as solubility (Higuchi and Connors, 1965), …

WebMar 22, 2024 · We also introduced the Higuchi and Connors method to analyze inclusion complex formed through solubilization and the pharmaceutical benefits that can be gained using CDs. In addition, the practical applications of CDs in nasal, ophthalmic, pulmonary, and rectal drug delivery are also described. CD applications for drug solubilization WebT. Higuchi, A. Connors Published 1965 Chemistry No Paper Link Available Save to Library Create Alert Cite 2,633 Citations Citation Type More Filters Development of Solvent-Free …

WebJan 1, 2011 · T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 (1965), pp. 117-212. Google Scholar [18] L. Greenspan. Humidity Fixed Points of Binary Saturated Aqueous Solutions. J Res Nat Bur Stand, 81A (1) (1977), pp. 89-96. CrossRef Google Scholar [19] WebTypes of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are …

WebThe shake-flask method is based on the phase solubility technique that was developed 40 years ago and is still the most reliable and widely used method for solubility measurement …

WebT K Higuchi, A Connors 31 Dec 1964 - Vol. 4, pp 212-217 About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The … flagging technique boulderingWebMay 9, 2007 · A phase solubility study was performed, according to the method reported by Higuchi and Connors, to evaluate the changes of isoflavone in the complexation state and the obtained diagrams suggested that it forms complexes with a stoichiometry of 1:1. flagging the lineWebJan 15, 2024 · Phase-solubility profiles and classification of drug/cyclodextrin complexes according to Higuchi and Connors (Higuchi and Connors, 1965). The phase solubility … can obsidian be found in michiganWebIt is a blood scihozonticide and active against all stages of Plasmodium falciparum. The drug is also used for the treatment of cerebral malaria as well as for the chloro- quine resistant cases [2-5]. Unfortunately, it is water- insoluble (17 µg/ml at room temperature) [6] and the formulation causes difficulties to the biopharmaceutical scientist. can observational studies be randomizedWebMar 28, 2014 · Solubility studies were performed according to the method reported by Higuchi and Connors and the phase solubility diagrams were plotted. The repaglinide-nanosponges complexes were prepared, lyophilized and the resulted inclusion complexes were characterized by FT-IR and NMR. can observation stay be longer than 48 hoursWebPhase-solubility studies Water solubility studies for both triterpenic acids were conducted by the Higuchi and Connors method [16] using a series of increasing concentrations of … can obsidian be burned by lava minecraftWebThe Higuchi窶鼎onnors phase-solubility method8)is very often used to determine K 1:1 , as a part of a formulation study. This method is based on the effect of a complex forming lig- and, e.g.CD, on the solubility of the drug. The intrinsic solu- bility (S 0 ) and the slope of the phase-solubility diagram are then used to calculate K 1:1 can obs edit recordings