WitrynaOrganic cation/carnitine transporter 2 (OCTN2, SLC22A5) has emerged as a viable target for drug delivery. OCTN2 is a Na + -dependent high-affinity transporter for L-carnitine and a Na + -independent transporter for organic cations. OCTN2 is expressed in the blood-brain barrier, heart, liver, kidney, intestinal tract and placenta … WitrynaOrganic Cation Transporter 1 and 3 Contribute to the High Accumulation of Dehydrocorydaline in the Heart Drug Metab Dispos. 2024 Oct;48 (10):1074 ...
O64515 - UniProt
Witryna1 mar 2005 · Urinary excretion of cationic xenobiotics is believed to be mediated by organic cation transporter (OCT and OCTN) families expressed on both basolateral and brush-border membranes of renal tubules, although the molecular mechanisms for targeting of these transporters to each membrane are poorly understood. Here, to … WitrynaOrganic cation/carnitine transporters transport carnitine, drugs, and xenobiotics (e.g. choline, acetylcarnitine, betaine, valproic acid), and are expressed in muscle, heart, … ces biggleswade
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Witryna2 dni temu · The finding is attributed to the appropriate cation rigidity, which enables organic diammoniums and inorganic octahedra to regulate their geometries to accommodate each other. This work explains the stability mechanism of DJ 2D perovskites and provides guidance for constructing highly stable candidates by … WitrynaInteractions between genetic and environmental factors, like exposure to stress, have an important role in the pathogenesis of mood-related psychiatric disorders, such as major depressive disorder. The polyspecific organic cation transporters (OCTs) were shown previously to be sensitive to the stress hormone corticosterone in vitro, suggesting … Witryna13 gru 2013 · OCTN2 - the Organic Cation Transporter Novel family member 2 (SLC22A5) is known to be a xenobiotic/drug transporter. It transports as well carnitine - a compound necessary for oxidation of fatty acids and mutations of its gene cause primary carnitine deficiency. Octn2 regulation by protein kinase C (PKC) was studied … ces best bluetooth headset