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Organic cation/carnitine transporter 3

WitrynaOrganic cation/carnitine transporter 2 (OCTN2, SLC22A5) has emerged as a viable target for drug delivery. OCTN2 is a Na + -dependent high-affinity transporter for L-carnitine and a Na + -independent transporter for organic cations. OCTN2 is expressed in the blood-brain barrier, heart, liver, kidney, intestinal tract and placenta … WitrynaOrganic Cation Transporter 1 and 3 Contribute to the High Accumulation of Dehydrocorydaline in the Heart Drug Metab Dispos. 2024 Oct;48 (10):1074 ...

O64515 - UniProt

Witryna1 mar 2005 · Urinary excretion of cationic xenobiotics is believed to be mediated by organic cation transporter (OCT and OCTN) families expressed on both basolateral and brush-border membranes of renal tubules, although the molecular mechanisms for targeting of these transporters to each membrane are poorly understood. Here, to … WitrynaOrganic cation/carnitine transporters transport carnitine, drugs, and xenobiotics (e.g. choline, acetylcarnitine, betaine, valproic acid), and are expressed in muscle, heart, … ces biggleswade https://smiths-ca.com

UniProt

Witryna2 dni temu · The finding is attributed to the appropriate cation rigidity, which enables organic diammoniums and inorganic octahedra to regulate their geometries to accommodate each other. This work explains the stability mechanism of DJ 2D perovskites and provides guidance for constructing highly stable candidates by … WitrynaInteractions between genetic and environmental factors, like exposure to stress, have an important role in the pathogenesis of mood-related psychiatric disorders, such as major depressive disorder. The polyspecific organic cation transporters (OCTs) were shown previously to be sensitive to the stress hormone corticosterone in vitro, suggesting … Witryna13 gru 2013 · OCTN2 - the Organic Cation Transporter Novel family member 2 (SLC22A5) is known to be a xenobiotic/drug transporter. It transports as well carnitine - a compound necessary for oxidation of fatty acids and mutations of its gene cause primary carnitine deficiency. Octn2 regulation by protein kinase C (PKC) was studied … ces best bluetooth headset

Organic cation/carnitine transporter OCTN3 is present in …

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Organic cation/carnitine transporter 3

Organic cation/carnitine transporter OCTN3 is present in …

WitrynaGene ID: 123122744, updated on 24-Aug-2024. Summary Other designations. organic cation/carnitine transporter 7-like WitrynaOne of the compounds necessary in the process of mitochondrial beta-oxidation and export of acyl moieties from peroxisomes is l-carnitine. Two Na-dependent plasma …

Organic cation/carnitine transporter 3

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Witryna15 lut 2024 · The Carnitine-Acylcarnitine Carrier is a member of the mitochondrial Solute Carrier Family 25 (SLC25), known as SLC25A20, involved in the electroneutral exchange of acylcarnitine and carnitine across the inner mitochondrial membrane. It acts as a master regulator of fatty acids β-oxidation and is known to be involved in … WitrynaSeveral SLC22 transporters in the human kidney and other tissues are thought to regulate endogenous small antioxidant molecules such as uric acid, ergothioneine, …

WitrynaPTHR24064:SF530 ORGANIC CATION/CARNITINE TRANSPORTER 4 1 hit; PTHR24064 SOLUTE CARRIER FAMILY 22 MEMBER 1 hit; PROSITE. View protein … WitrynaThis chapter focuses on transporters for two major categories of solutes: organic cations and zwitterions. For organic cations, the …

Witryna1 sty 2000 · OCTN2 is an organic cation/carnitine transporter that is responsible for Na(+)-coupled transport of carnitine in the kidney and other tissues. We investigated the interaction of several beta-lactam antibiotics with OCTN2 using human cell lines that express the transporter constitutively as well as using cloned human and rat … Witryna9 cze 2010 · The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of …

WitrynaAt present metformin PK/PD, distribution, and excretion were studied in Oct1/Oct2-knockout mice. Metformin clearance was reduced 4.5-fold from renal blood flow to unbound glomerular filtration rate, and volume of distribution was reduced 3.5-fold in Oct1/Oct2-knockout mice. buzz aldrin watch for saleWitryna2.2.3 Organic cation transporters. Organic cation transporters are one of the major transporters classified in the SLC22A superfamily. Three members of the OCT … buzz aldrin twitter antarcticaWitrynaOne of the compounds necessary in the process of mitochondrial β-oxidation and export of acyl moieties from peroxisomes is l-carnitine. Two Na-dependent plasma … cesboard gov.phWitryna22 gru 2000 · We have already shown that a defect of the organic cation/carnitine transporter OCTN2 is a primary cause of systemic carnitine deficiency. In the … cesboard exam schedule 2022Witryna1 mar 2005 · Urinary excretion of cationic xenobiotics is believed to be mediated by organic cation transporter (OCT and OCTN) families expressed on both basolateral … buzz aldrin visits antarcticaWitrynathe carnitine/organic cation transporter 2 (OCTN2, SLC22A5) but not by the organic cation transporter 1 (OCT1) and N1 (OCTN1). Non-labeled colistin inhibited the OCTN2-mediated transport of [3H]L-carnitine in a non-competitive manner and that of [14C]tetraethylammonium bromide ([ C]TEA) in a competi-tive manner. buzz aldrin walk on the moon 1969WitrynaOrganic cation/carnitine transporter 2: BLAST Add. Sequence: Expand table. Proteomic databases. PaxDb. O64515; ProteomicsDB. 250863; Expression. Tissue specificity. Weakly expressed in roots, including tips and initiation site of lateral roots, siliques and flowers, especially in pollen and stigma. 3 publications. buzz aldrin video about moon landing